Structure of PDB 1r5c Chain A

Receptor sequence

>1r5cA (length=124) Species: 9913 (Bos taurus)

KESAAAKFERQHMDSGNSPSSSSNYCNLMMCCRKMTQGKCKPVNTFVHES
LADVKAVCSQKKVTCKNGQTNCYQSKSTMRITDCRETGSSKYPNCAYKTT
QVEKHIIVACGGKPSVPVHFDASV

3D structure

• PDB: 1r5c Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H12 K41 H119 F120 D121
• Catalytic site (residue number reindexed from 1): H12 K41 H119 F120 D121
• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CPA	A	V43 N44 T45 N67 Q69 N71 A109 H119 F120	V43 N44 T45 N67 Q69 N71 A109 H119 F120

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0016829 lyase activity
• GO:0042802 identical protein binding

Biological Process

• GO:0050830 defense response to Gram-positive bacterium
• GO:0051607 defense response to virus

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1r5c, PDBe:1r5c, PDBj:1r5c
• PDBsum: 1r5c
• PubMed: 15048772
• UniProt: P00669|RNS_BOVIN Seminal ribonuclease (Gene Name=SRN)