Structure of PDB 1r4w Chain A

Receptor sequence
>1r4wA (length=221) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GPAPRVLELFYDVLSPYSWLGFEVLCRYQHLWNIKLKLRPALLAGIMKDS
GNQPPAMVPHKGQYILKEIPLLKQLFQVPMSVPKDFFGEHVKKGTVNAMR
FLTAVSMEQPEMLEKVSRELWMRIWSRDEDITESQNILSAAEKAGMATAQ
AQHLLNKISTELVKSKLRETTGAACKYGAFGLPTTVAHVDGKTYMLFGSD
RMELLAYLLGEKWMGPVPPTL
3D structure
PDB1r4w Parallel Evolutionary Pathways for Glutathione Transferases: Structure and Mechanism of the Mitochondrial Class Kappa Enzyme rGSTK1-1
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A S16 Y18 F181 G182 L183 F198 G199 S200 D201 S15 Y17 F180 G181 L182 F197 G198 S199 D200 MOAD: Kd=90uM
PDBbind-CN: -logKd/Ki=4.05,Kd=90uM
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0030855 epithelial cell differentiation
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:1r4w, PDBe:1r4w, PDBj:1r4w
PDBsum1r4w
PubMed14717589
UniProtP24473|GSTK1_RAT Glutathione S-transferase kappa 1 (Gene Name=Gstk1)

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