Structure of PDB 1r3s Chain A

Receptor sequence
>1r3sA (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCR
SPEACCELTLQPLRRFPLDAAIIFSGILVVPQALGMEVTMVPGKGPSFPE
PLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWT
LMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAG
AQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMII
FAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCAL
YASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKH
SRLLRQ
3D structure
PDB1r3s Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R37 R41 R50 G86 Y164
Catalytic site (residue number reindexed from 1) R27 R31 R40 G76 Y154
Enzyme Commision number 4.1.1.37: uroporphyrinogen decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1CP A R37 A39 F46 R50 F55 I82 F84 S85 I87 M100 P106 F154 Y164 F217 S219 H339 R27 A29 F36 R40 F45 I72 F74 S75 I77 M90 P96 F144 Y154 F207 S209 H329
Gene Ontology
Molecular Function
GO:0004853 uroporphyrinogen decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0006787 porphyrin-containing compound catabolic process
GO:0042168 heme metabolic process
GO:0048034 heme O biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1r3s, PDBe:1r3s, PDBj:1r3s
PDBsum1r3s
PubMed14633982
UniProtP06132|DCUP_HUMAN Uroporphyrinogen decarboxylase (Gene Name=UROD)

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