Structure of PDB 1r3q Chain A

Receptor sequence
>1r3qA (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
GFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTC
RSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFP
EPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPW
TLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVA
GAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI
IFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCA
LYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHK
HSRLLRQ
3D structure
PDB1r3q Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R37 R41 R50 D86 Y164
Catalytic site (residue number reindexed from 1) R28 R32 R41 D77 Y155
Enzyme Commision number 4.1.1.37: uroporphyrinogen decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1CP A R37 A39 R41 R50 F55 I82 S85 D86 I87 M100 P106 F154 Y164 F217 S219 H339 R28 A30 R32 R41 F46 I73 S76 D77 I78 M91 P97 F145 Y155 F208 S210 H330
Gene Ontology
Molecular Function
GO:0004853 uroporphyrinogen decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0006787 porphyrin-containing compound catabolic process
GO:0042168 heme metabolic process
GO:0048034 heme O biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1r3q, PDBe:1r3q, PDBj:1r3q
PDBsum1r3q
PubMed14633982
UniProtP06132|DCUP_HUMAN Uroporphyrinogen decarboxylase (Gene Name=UROD)

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