Structure of PDB 1r0z Chain A

Receptor sequence
>1r0zA (length=275) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGELLEKVQKHSSDENNVSFSHLCLVGNPVLKNIN
LNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFS
WIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGG
VTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLM
ANKTRILVTSKMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLM
GYDTFDQFTEERRSSILTETLRRFS
3D structure
PDB1r0z Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 D572 T70 Q98 D177
BS02 ATP A W401 E425 F430 T460 G461 S462 G463 K464 T465 S466 W12 E30 F35 T65 G66 S67 G68 K69 T70 S71
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1r0z, PDBe:1r0z, PDBj:1r0z
PDBsum1r0z
PubMed14685259
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

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