Structure of PDB 1r0x Chain A

Receptor sequence
>1r0xA (length=264) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGELLEKSFSHLCLVGNPVLKNINLNIEKGEMLAI
TGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENI
IFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARI
SLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSK
MEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEE
RRSSILTETLRRFS
3D structure
PDB1r0x Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 T59 Q87
BS02 ATP A W401 L409 T460 G461 S462 G463 K464 T465 S466 W12 L20 T54 G55 S56 G57 K58 T59 S60 MOAD: Kd=149uM
PDBbind-CN: -logKd/Ki=3.83,Kd=149uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1r0x, PDBe:1r0x, PDBj:1r0x
PDBsum1r0x
PubMed14685259
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

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