Structure of PDB 1qxs Chain A

Receptor sequence

>1qxsA (length=359) Species: 5693 (Trypanosoma cruzi)

MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQM
RYDTVHGKFKYEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWG
KLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNH
HEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQ
KTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRV
PTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSAD
FINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHM
ASKDRSARL

3D structure

• PDB: 1qxs Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-d-glyceric acid.
• Chain: A
• Resolution: 2.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C166 H194
• Catalytic site (residue number reindexed from 1): C166 H194
• Enzyme Commision number: 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G9 G11 R12 I13 V37 D38 A90 T111 L113 S134 A135 C166 A198 N335 Y339	G9 G11 R12 I13 V37 D38 A90 T111 L113 S134 A135 C166 A198 N335 Y339
BS02	S70	A	C166 T167 H194 T197 T199 T226 S247 R249	C166 T167 H194 T197 T199 T226 S247 R249

Gene Ontology

Molecular Function

• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005829 cytosol
• GO:0020015 glycosome

External links

• PDB: RCSB:1qxs, PDBe:1qxs, PDBj:1qxs
• PDBsum: 1qxs
• PubMed: 14622286
• UniProt: P22513|G3PG_TRYCR Glyceraldehyde-3-phosphate dehydrogenase, glycosomal