Structure of PDB 1qtq Chain A

Receptor sequence

>1qtqA (length=529) Species: 562 (Escherichia coli) [Search protein sequence]

TNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDY
KGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLH
AYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALF
EKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCI
YPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYE
FSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIR
EFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQ
GEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGK
EVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLGVIHWVSAAHALPVE
IRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQF
EREGYFCLDSRHSTAEKPVFNRTVGLRDT

3D structure

PDB

1qtq How glutaminyl-tRNA synthetase selects glutamine.

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.1.1.18: glutamine--tRNA ligase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Q13 E34 T68 N69 I129 R130 R133 T135 L136 T137 G168 P181 F182 I183 V189 R192 K194 M210 Y211 F233 Q234 D235 R238 I313 T316 K317 Q318 N320 T321 E323 S326 R341 P369 Q399 K401 R402 R410 R412 N413 V455 Q517 E519 R520 R545	Q6 E27 T61 N62 I122 R123 R126 T128 L129 T130 G161 P174 F175 I176 V182 R185 K187 M203 Y204 F226 Q227 D228 R231 I306 T309 K310 Q311 N313 T314 E316 S319 R334 P362 Q392 K394 R395 R403 R405 N406 V437 Q499 E501 R502 R527	PDBbind-CN: Ki=1.32uM
BS02	QSI	A	P32 P33 G42 H43 D66 Y211 H215 C229 T230 R260 L261 K270	P25 P26 G35 H36 D59 Y204 H208 C222 T223 R253 L254 K263

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004819	glutamine-tRNA ligase activity
GO:0005524	ATP binding

	Biological Process
GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006424	glutamyl-tRNA aminoacylation
GO:0006425	glutaminyl-tRNA aminoacylation
GO:0043039	tRNA aminoacylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1qtq, PDBe:1qtq, PDBj:1qtq
PDBsum	1qtq
PubMed	9562563
UniProt	P00962\|SYQ_ECOLI Glutamine--tRNA ligase (Gene Name=glnS)

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