Structure of PDB 1qsc Chain A

Receptor sequence
>1qscA (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
QLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGR
IPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALL
RWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLF
CPVSKMEAKNSYVRDDAIFIKAIVDLTGL
3D structure
PDB1qsc Crystallographic analysis of CD40 recognition and signaling by human TRAF2.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R393 Y395 D399 F410 F447 R448 S455 A466 S467 G468 P470 R71 Y73 D77 F88 F125 R126 S133 A144 S145 G146 P148
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1qsc, PDBe:1qsc, PDBj:1qsc
PDBsum1qsc
PubMed10411888
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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