Structure of PDB 1qrl Chain A

Receptor sequence
>1qrlA (length=214) Species: 2210 (Methanosarcina thermophila) [Search protein sequence]
MQEITVDEFSNIRENPVTPWNPEPSAPVIDPTAYIDPQASVIGEVTIGAN
VMVSPMASIRSDEGMPIFVGDRSNVQDGVVLHALETINEEGEPIEDNIVE
VDGKEYAVYIGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGNNCV
LEPRSAAIGVTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVV
YVNVHLAEGYKETS
3D structure
PDB1qrl A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E62 Q75 H81 E84 H117 H122 N202
Catalytic site (residue number reindexed from 1) E63 Q76 H82 E85 H118 H123 N203
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H81 H122 H82 H123
BS02 BCT A E62 H81 H122 E63 H82 H123 BindingDB: Ki=42000000nM
External links
PDB RCSB:1qrl, PDBe:1qrl, PDBj:1qrl
PDBsum1qrl
PubMed10924115
UniProtP40881|CAH_METTT Carbonic anhydrase (Gene Name=MSTHT_0588)

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