Structure of PDB 1qr1 Chain A

Receptor sequence
>1qr1A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYG
CDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAA
HVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGQEQRYTCHVQHEGLPKPLTLRWE
3D structure
PDB1qr1 Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y7 E63 H70 T73 D77 L81 Y84 Y99 Y116 T143 W147 Q155 Y159 W167 Y171 Y7 E63 H70 T73 D77 L81 Y84 Y99 Y116 T143 W147 Q155 Y159 W167 Y171
External links
PDB RCSB:1qr1, PDBe:1qr1, PDBj:1qr1
PDBsum1qr1
PubMed10593938
UniProtP04439|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)

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