Structure of PDB 1qle Chain A

Receptor sequence

>1qleA (length=538) Species: 266 (Paracoccus denitrificans)

GFFTRWFMSTNHKDIGILYLFTAGIVGLISVCFTVYMRMELQHPGVQYMC
LEGARLIADASAECTPNGHLWNVMITYHGVLMMFFVVIPALFGGFGNYFM
PLHIGAPDMAFPRLNNLSYWMYVCGVALGVASLLAPGGNDQMGSGVGWVL
YPPLSTTEAGYSMDLAIFAVHVSGASSILGAINIITTFLNMRAPGMTLFK
VPLFAWSVFITAWLILLSLPVLAGAITMLLMDRNFGTQFFDPAGGGDPVL
YQHILWFFGHPEVYIIILPGFGIISHVISTFAKKPIFGYLPMVLAMAAIG
ILGFVVWAHHMYTAGMSLTQQAYFMLATMTIAVPTGIKVFSWIATMWGGS
IEFKTPMLWAFGFLFLFTVGGVTGVVLSQAPLDRVYHDTYYVVAHFHYVM
SLGAVFGIFAGVYYWIGKMSGRQYPEWAGQLHFWMMFIGSNLIFFPQHFL
GRQGMPRRYIDYPVEFAYWNNISSIGAYISFASFLFFIGIVFYTLFAGKR
VNVPNYWNEHADTLEWTLPSPPPEHTFETLPKREDWDR

3D structure

• PDB: 1qle The Cytochrome C Oxidase from Paracoccus Denitrificans Does not Change the Metal Center Ligation Upon Reduction
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y35 I45 F49 M53 I91 H94 N113 D124 N131 S134 Y138 W164 S192 S193 G196 T203 H276 E278 Y280 S291 P307 H325 H326 T351 K354 H411 F412 H413 R473 R474
• Catalytic site (residue number reindexed from 1): Y19 I29 F33 M37 I75 H78 N97 D108 N115 S118 Y122 W148 S176 S177 G180 T187 H260 E262 Y264 S275 P291 H309 H310 T335 K338 H395 F396 H397 R457 R458
• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEA	A	A39 G40 V47 T50 R54 H94 M98 G163 W164 Y406 V409 F412 H413 M416 S417 M452 R474 F500	A23 G24 V31 T34 R38 H78 M82 G147 W148 Y390 V393 F396 H397 M400 S401 M436 R458 F484
BS02	HEA	A	V279 Y280 H325 H326 T351 G352 G387 G390 L393 D399 H403 V408 H411 F412 V415 M416 R473	V263 Y264 H309 H310 T335 G336 G371 G374 L377 D383 H387 V392 H395 F396 V399 M400 R457
BS03	CU	A	H276 H325 H326	H260 H309 H310
BS04	CA	A	E56 H59 P60 G61 Q63	E40 H43 P44 G45 Q47
BS05	MN	A	H403 D404	H387 D388

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0045277 respiratory chain complex IV

External links

• PDB: RCSB:1qle, PDBe:1qle, PDBj:1qle
• PDBsum: 1qle
• PubMed: 10559205
• UniProt: P98002|COX1B_PARDE Cytochrome c oxidase subunit 1-beta (Gene Name=ctaDII)