Structure of PDB 1ql6 Chain A

Receptor sequence
>1ql6A (length=281) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSA
EEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGE
LFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDD
MNIKLTDFGFSCQLDPGEKLRSVCGTPSYLAPEIIECSMNDNHPGYGKEV
DMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTV
KDLVSRFLVVQPQKRYTAEEALAHPFFQQYV
3D structure
PDB1ql6 Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 N154 D167 T186
Catalytic site (residue number reindexed from 1) D139 K141 N144 D157 T176
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.19: phosphorylase kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A L25 V33 A46 K48 M106 E110 L156 D167 L15 V23 A36 K38 M96 E100 L146 D157
BS02 MN A N154 D167 N144 D157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004689 phosphorylase kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005964 phosphorylase kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ql6, PDBe:1ql6, PDBj:1ql6
PDBsum1ql6
PubMed10545198
UniProtP00518|PHKG1_RABIT Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Gene Name=PHKG1)

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