Structure of PDB 1qku Chain A

Receptor sequence
>1qkuA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLA
DRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQ
HQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH
3D structure
PDB1qku Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A E353 L387 F404 H524 L525 E53 L87 F104 H224 L225 PDBbind-CN: -logKd/Ki=9.59,Kd=0.26nM
BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1qku, PDBe:1qku, PDBj:1qku
PDBsum1qku
PubMed11278577
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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