Structure of PDB 1qkt Chain A

Receptor sequence
>1qktA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQR
LAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLYDLLLEMLDAHRLHA
3D structure
PDB1qkt Crystal Structure of a Mutant Heralpha Ligand- Binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A L346 E353 L387 F404 M421 L43 E50 L84 F101 M118 MOAD: Kd=0.92nM
PDBbind-CN: -logKd/Ki=9.04,Kd=0.92nM
BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1qkt, PDBe:1qkt, PDBj:1qkt
PDBsum1qkt
PubMed11278577
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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