Structure of PDB 1qiw Chain A

Receptor sequence

>1qiwA (length=145) Species: 9913 (Bos taurus)

DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDM
INEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYIS
AAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

3D structure

• PDB: 1qiw A New Potent Calmodulin Antagonist with Arylalkylamine Structure: Crystallographic, Spectroscopic and Functional Studies
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): V35
• Catalytic site (residue number reindexed from 1): V34

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D20 D22 D24 T26 E31	D19 D21 D23 T25 E30
BS02	CA	A	D56 D58 N60 T62 E67	D55 D57 N59 T61 E66
BS03	CA	A	D93 D95 N97 Y99 E104	D92 D94 N96 Y98 E103
BS04	CA	A	D129 D131 D133 Q135 E140	D128 D130 D132 Q134 E139
BS05	DPD	A	F19 L32 M36 M51 M71 M72 E84	F18 L31 M35 M50 M70 M71 E83	MOAD: Kd=18nM
BS06	DPD	A	E11 M72 M124 M144 M145	E10 M71 M123 M143 M144	MOAD: Kd=18nM

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0046872 metal ion binding

Biological Process

• GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
• GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

• GO:0000922 spindle pole
• GO:0005737 cytoplasm
• GO:0005819 spindle
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1qiw, PDBe:1qiw, PDBj:1qiw
• PDBsum: 1qiw
• PubMed: 10731425
• UniProt: P62157|CALM_BOVIN Calmodulin (Gene Name=CALM)