Structure of PDB 1qf9 Chain A

Receptor sequence
>1qf9A (length=194) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
MEKSKPNVVFVLGGPGSGKGTQCANIVRDFGWVHLSAGDLLRQEQQSGSK
DGEMIATMIKNGEIVPSIVTVKLLKNAIDANQGKNFLVDGFPRNEENNNS
WEENMKDFVDTKFVLFFDCPEEVMTQRLLKRGESSGRSDDNIESIKKRFN
TFNVQTKLVIDHYNKFDKVKIIPANRDVNEVYNDVENLFKSMGF
3D structure
PDB1qf9 pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K19 R93 R131 R137 R148
Catalytic site (residue number reindexed from 1) K19 R93 R131 R137 R148
Enzyme Commision number 2.7.4.14: UMP/CMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A P15 G16 K19 R93 R131 R137 R148 P15 G16 K19 R93 R131 R137 R148
BS02 ADP A G16 G18 K19 G20 T21 R127 R131 V178 G16 G18 K19 G20 T21 R127 R131 V178
BS03 C5P A G38 L41 R42 E63 I64 V65 G90 R93 R137 R148 G38 L41 R42 E63 I64 V65 G90 R93 R137 R148
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004127 (d)CMP kinase activity
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019205 nucleobase-containing compound kinase activity
GO:0033862 UMP kinase activity
GO:0036430 CMP kinase activity
GO:0036431 dCMP kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0043100 pyrimidine nucleobase salvage
GO:0043173 nucleotide salvage
GO:0046705 CDP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
GO:0072528 pyrimidine-containing compound biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1qf9, PDBe:1qf9, PDBj:1qf9
PDBsum1qf9
PubMed10426946
UniProtP20425|KCY_DICDI UMP-CMP kinase (Gene Name=pyrK)

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