Structure of PDB 1qb0 Chain A

Receptor sequence
>1qb0A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVI
VDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHC
EFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFC
EPQDYRPMNHEAFKDELKTFRLKTRSW
3D structure
PDB1qb0 Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A C473 E474 F475 S477 E478 R479 S549 W550 C100 E101 F102 S104 E105 R106 S176 W177
BS02 CL A L445 T547 L72 T174
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:1qb0, PDBe:1qb0, PDBj:1qb0
PDBsum1qb0
PubMed10543950
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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