Structure of PDB 1q92 Chain A

Receptor sequence
>1q92A (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
GRALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYG
RLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSP
IKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITG
AEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB1q92 Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D41 D43 D176
Catalytic site (residue number reindexed from 1) D9 D11 D144
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D41 D43 D176 D9 D11 D144
BS02 DRM A D43 F49 F75 W76 V77 F102 S131 I133 K165 R177 D11 F17 F43 W44 V45 F70 S99 I101 K133 R145
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1q92, PDBe:1q92, PDBj:1q92
PDBsum1q92
PubMed15044615
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

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