Structure of PDB 1q91 Chain A

Receptor sequence
>1q91A (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
RALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGR
LRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPI
KMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGA
EPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB1q91 Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D41 D43 D176
Catalytic site (residue number reindexed from 1) D8 D10 D143
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A D41 M42 D43 T130 S131 K165 D8 M9 D10 T97 S98 K132
BS02 MG A D41 D43 D176 D8 D10 D143
BS03 DPB A F49 F75 W76 V77 W96 S131 I133 K134 R163 F16 F42 W43 V44 W63 S98 I100 K101 R130 MOAD: Ki=70uM
PDBbind-CN: -logKd/Ki=4.15,Ki=70uM
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1q91, PDBe:1q91, PDBj:1q91
PDBsum1q91
PubMed15044615
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

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