Structure of PDB 1q7l Chain A

Receptor sequence
>1q7lA (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
EEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAP
GYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYI
YARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGME
LFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRV
3D structure
PDB1q7l Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.14: N-acyl-aliphatic-L-amino acid amidohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H80 D113 E175 H74 D107 E169
BS02 ZN A D113 E148 D107 E142
BS03 GLY A D113 E147 E148 E175 D107 E141 E142 E169
Gene Ontology
Molecular Function
GO:0004046 aminoacylase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006520 amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q7l, PDBe:1q7l, PDBj:1q7l
PDBsum1q7l
PubMed12933810
UniProtQ03154|ACY1_HUMAN Aminoacylase-1 (Gene Name=ACY1)

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