Structure of PDB 1q79 Chain A

Receptor sequence

>1q79A (length=470) Species: 9913 (Bos taurus)

HYGITSPISLAAPKETDCLLTQKLVETLKPFGVFEEEEELQRRILILGKL
NNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALC
VAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDI
LFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNID
NFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTL
VHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITP
AYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFF
QKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNP
QSFPAPKENPDKEEFRTMWVIGLVFKDLTYDIQSFTDTVYRQAINSKMFE
VDMKIAAMHVKRKQLHQLLP

3D structure

• PDB: 1q79 Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S102 D113 D115 D167 K228 Y237
• Catalytic site (residue number reindexed from 1): S84 D95 D97 D149 K210 Y219
• Enzyme Commision number: 2.7.7.19: polynucleotide adenylyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	D113 D115 D167	D95 D97 D149
BS02	MN	A	D113 D115	D95 D97
BS03	3AT	A	G101 S102 D113 D115 D167 V247	G83 S84 D95 D97 D149 V229

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0016779 nucleotidyltransferase activity
• GO:1990817 poly(A) RNA polymerase activity

Biological Process

• GO:0031123 RNA 3'-end processing

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:1q79, PDBe:1q79, PDBj:1q79
• PDBsum: 1q79
• PubMed: 15328606
• UniProt: P25500|PAPOA_BOVIN Poly(A) polymerase alpha (Gene Name=PAPOLA)