Structure of PDB 1q51 Chain A

Receptor sequence
>1q51A (length=271) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVD
ELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQLHILEVQRLI
RFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDG
GYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVG
LQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAV
EGRDAFLQKRPPDWSPFPRYF
3D structure
PDB1q51 Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 H135 G161 S164 D185 S190 D192 G193 A279 Y287
Catalytic site (residue number reindexed from 1) G88 H92 G118 S121 D142 S147 D149 G150 A236 Y244
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAA A V57 R58 K95 S103 G105 D106 Q107 W157 G160 G161 T184 V40 R41 K78 S86 G88 D89 Q90 W114 G117 G118 T141
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q51, PDBe:1q51, PDBj:1q51
PDBsum1q51
PubMed12909628
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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