Structure of PDB 1q4x Chain A

Receptor sequence
>1q4xA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
GHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPGKVDLEAFSHF
TKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD
PESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVAL
LQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLL
MKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
3D structure
PDB1q4x Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G24 A F269 F272 T273 L330 N331 L346 H435 F451 F455 F47 F50 T51 L108 N109 L124 H213 F229 F233 PDBbind-CN: -logKd/Ki=9.48,Kd=0.33nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1q4x, PDBe:1q4x, PDBj:1q4x
PDBsum1q4x
PubMed14673100
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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