Structure of PDB 1q3u Chain A

Receptor sequence

>1q3uA (length=332) Species: 10678 (Punavirus P1) [Search protein sequence]

NLPALPVDATSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLN
NRKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSD
SNAVSLVMRRIRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIR
NLAFLGIAYNTLLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGV
EKALSLGVTKLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTR
ALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEI
MQAGGWTNVNIVMNYIRNLDSETGAMVRLLED

3D structure

PDB

1q3u Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F37 S38 H40 T41 M97 R173 I174 A175 K201 R243 K244 N245 R259 E262 K276 R282 S287 G288 H289	F28 S29 H31 T32 M88 R164 I165 A166 K192 R234 K235 N236 R250 E253 K267 R273 S278 G279 H280
BS02	dna	A	M44 S47 R50 R81 L83 A84 K86 T87 A131 K132 Q156 R159 T202 R241 V242 K244 L256 S257 R259 A260 R282 N317 Y324	M35 S38 R41 R72 L74 A75 K77 T78 A122 K123 Q147 R150 T193 R232 V233 K235 L247 S248 R250 A251 R273 N308 Y315

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1q3u, PDBe:1q3u, PDBj:1q3u
PDBsum	1q3u
PubMed	12954782
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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