Structure of PDB 1q3c Chain A

Receptor sequence
>1q3cA (length=250) Species: 562 (Escherichia coli) [Search protein sequence]
AGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKTYQSQLIGQHVTHVETRG
KALLTHFSNDLTLYSHNQLYGVWRVVDTGETTRVLRVKLQTADKTILLYS
ASDIEMLRPEQLTTHPFLQRVGPDVLDPNLTPEVVKERLLSPRFRNRQFA
GLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLEI
PRFSYATRGENKHHGALFRFKVFHRDGEPCERCGSIIEKTPFYWCPGCQH
3D structure
PDB1q3c Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C237 C257 C260 C230 C245 C248
BS02 MG A H184 H262 H180 H250
Gene Ontology
Molecular Function
GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1q3c, PDBe:1q3c, PDBj:1q3c
PDBsum1q3c
PubMed16145054
UniProtP50465|END8_ECOLI Endonuclease 8 (Gene Name=nei)

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