Structure of PDB 1q22 Chain A

Receptor sequence
>1q22A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
SDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIIT
YPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDPR
LMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPG
TPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGS
VERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRG
AFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDE
3D structure
PDB1q22 Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K70 H125 S155
Catalytic site (residue number reindexed from 1) K53 H105 S135
Enzyme Commision number 2.8.2.2: alcohol sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P A K70 G72 T73 T74 W75 R147 S155 Y210 F246 F272 L273 R274 K275 G276 K53 G55 T56 T57 W58 R127 S135 Y190 F226 F252 L253 R254 K255 G256
BS02 AND A Y44 W98 W103 H125 Y257 Y27 W81 W86 H105 Y237
Gene Ontology
Molecular Function
GO:0008146 sulfotransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1q22, PDBe:1q22, PDBj:1q22
PDBsum1q22
PubMed12923182
UniProtO00204|ST2B1_HUMAN Sulfotransferase 2B1 (Gene Name=SULT2B1)

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