Structure of PDB 1q1z Chain A

Receptor sequence
>1q1zA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
KLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTW
MIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDSPRLMSSHLP
IQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLR
DFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGF
LGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGV
CGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDE
3D structure
PDB1q1z Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K70 H125 S155
Catalytic site (residue number reindexed from 1) K45 H98 S128
Enzyme Commision number 2.8.2.2: alcohol sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P A K70 G72 T73 T74 W75 R147 S155 Y210 F246 F272 L273 R274 K275 G276 K45 G47 T48 T49 W50 R120 S128 Y183 F219 F245 L246 R247 K248 G249
Gene Ontology
Molecular Function
GO:0008146 sulfotransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1q1z, PDBe:1q1z, PDBj:1q1z
PDBsum1q1z
PubMed12923182
UniProtO00204|ST2B1_HUMAN Sulfotransferase 2B1 (Gene Name=SULT2B1)

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