Structure of PDB 1pvn Chain A

Receptor sequence
>1pvnA (length=362) [Search protein sequence]
AKYYNEPCHTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLK
IPLVSAIMQSVSGEKMAIALAREGGISFIFGSQSIESQAAMVHAVKNFRY
LVGAGINTRDFRERVPALVEAGADVLCIDSSDGFSEWQKITIGWIREKYG
DKVKVGAGNIVDGEGFRYLADAGADFIKIGIGGGSICITREQKGIGRGQA
TAVIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMTLALAMGADFIMLGR
YFARFEESPTRKVTINGSVMKEYWGEGSSRARNWQRYDLGGKQKLSFEEG
VDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQSKAKITLVSSVS
IVEGGAHDVIVK
3D structure
PDB1pvn The Immunosuppressive Agent Mizoribine Monophosphate Forms a Transition State Analogue Complex with Inosine Monophosphate Dehydrogenase
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MZP A A57 M59 G316 S317 I318 C319 D358 L380 G381 R382 Y405 G407 E408 G409 R418 Y419 E431 G432 A56 M58 G184 S185 I186 C187 D226 L248 G249 R250 Y273 G275 E276 G277 R286 Y287 E299 G300 MOAD: Ki=0.15nM
PDBbind-CN: -logKd/Ki=9.82,Ki=0.15nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1pvn, PDBe:1pvn, PDBj:1pvn
PDBsum1pvn
PubMed12549902
UniProtP50097|IMDH_TRIFO Inosine-5'-monophosphate dehydrogenase (Gene Name=IMPDH)

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