Structure of PDB 1pvg Chain A

Receptor sequence
>1pvgA (length=378) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTI
VPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPI
EIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEF
ILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRF
GMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLK
SLIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQ
IVKKISEILKKVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFG
SRCEIPLEYINKIMKTDLATRMFEIADA
3D structure
PDB1pvg Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A N70 N74 I104 I120 F121 S127 S128 G140 R141 N142 G143 Y144 G145 A146 K147 K367 N64 N68 I98 I114 F115 S121 S122 G134 R135 N136 G137 Y138 G139 A140 K141 K339
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:1pvg, PDBe:1pvg, PDBj:1pvg
PDBsum1pvg
PubMed12963818
UniProtP06786|TOP2_YEAST DNA topoisomerase 2 (Gene Name=TOP2)

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