Structure of PDB 1pu9 Chain A

Receptor sequence
>1pu9A (length=163) Species: 5911 (Tetrahymena thermophila) [Search protein sequence]
LLDFDILTNDGTHRNMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHHESM
VILKNKQKVIGGICFRQYKPQRFAEVAFLAVTANEQVRGYGTRLMNKFKD
HMQKQNIEYLLTYADNFAIGYFKKQGFTKEHRMPQEKWKGYIKDYDGGTL
MECYIHPYVDYGR
3D structure
PDB1pu9 Structural basis for histone and phospho-histone binding by the GCN5 histone acetyltransferase
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y115 F120 E122 V123 A124 L126 L158 I189 Y192
Catalytic site (residue number reindexed from 1) Y68 F73 E75 V76 A77 L79 L111 I142 Y145
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K79 M80 E83 Y84 K87 L88 E122 V123 A124 F125 L126 T159 D162 N163 F164 F169 K32 M33 E36 Y37 K40 L41 E75 V76 A77 F78 L79 T112 D115 N116 F117 F122
BS02 COA A Q76 L77 L126 A127 V128 Q133 V134 G136 G138 T139 F164 Q29 L30 L79 A80 V81 Q86 V87 G89 G91 T92 F117
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:1pu9, PDBe:1pu9, PDBj:1pu9
PDBsum1pu9
PubMed14536085
UniProtQ27198

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