Structure of PDB 1pn4 Chain A

Receptor sequence
>1pn4A (length=272) Species: 5482 (Candida tropicalis) [Search protein sequence]
PVWRFDDRDVILYNIALGATTKQLKYVYENDSDFQVIPTFGHLITFNSGK
SQNSFAKLLRNFNPMLLLHGEHYLKVHSWPPPTEGEIKTTFEPIATTPKG
TNVVIVHGSKSVDNKSGELIYSNEATYFIRNCQADNKVYADRPAFATNQF
LAPKRAPDYQVDVPVSEDLAALYRLSGDRNPLQIDPNFAKGAKFPKPILH
GMCTYGLSAKALIDKFGMFNEIKARFTGIVFPGETLRVLAWKESDDTIVF
QTHVVDRGTIAINNAAIKLVGD
3D structure
PDB1pn4 A Two-domain Structure of One Subunit Explains Unique Features of Eukaryotic Hydratase 2.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 Q187 I202 G205
Catalytic site (residue number reindexed from 1) D178 Q183 I198 G201
Enzyme Commision number 1.1.1.n12: (3R)-hydroxyacyl-CoA dehydrogenase.
4.2.1.119: enoyl-CoA hydratase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HDC A F50 L72 H73 G74 K103 Y131 F132 D182 N184 Q187 G205 R229 F230 T231 G232 I233 F46 L68 H69 G70 K99 Y127 F128 D178 N180 Q183 G201 R225 F226 T227 G228 I229
External links
PDB RCSB:1pn4, PDBe:1pn4, PDBj:1pn4
PDBsum1pn4
PubMed15051722
UniProtP22414|FOX2_CANTR Peroxisomal hydratase-dehydrogenase-epimerase

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