Structure of PDB 1plk Chain A

Receptor sequence
>1plkA (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVGGGKSALTQIQNHFVYDIEDSYRKQVVIDGTCLLDDTAGQEE
YSAMRDYMRTGEGFVFAINNTKSFEDIHQYREQIKRKDSDDVPMLVGNKC
DLAGRTVESRQADARSYGIETSAKTRQVEDAFYLVREIRQH
3D structure
PDB1plk Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A K16 S17 T58 K12 S13 T45
BS02 GTP A G13 G15 K16 S17 A18 A59 G60 Q61 N116 A146 K147 G10 G11 K12 S13 A14 A46 G47 Q48 N98 A123 K124
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1plk, PDBe:1plk, PDBj:1plk
PDBsum1plk
PubMed15299412
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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