Structure of PDB 1pl6 Chain A

Receptor sequence
>1pl6A (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHY
WEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRE
NDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEE
GALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVV
VTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECT
GAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYC
NTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCD
PSDQNP
3D structure
PDB1pl6 X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344
Catalytic site (residue number reindexed from 1) C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344
Enzyme Commision number 1.1.1.-
1.1.1.14: L-iditol 2-dehydrogenase.
1.1.1.4: (R,R)-butanediol dehydrogenase.
1.1.1.56: ribitol 2-dehydrogenase.
1.1.1.9: D-xylulose reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C44 H69 C44 H69
BS02 NAD A G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 F297 R298 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 F297 R298
BS03 572 A C44 S46 I56 F59 H69 E155 L274 F297 C44 S46 I56 F59 H69 E155 L274 F297 MOAD: Ki=154nM
BindingDB: IC50=246nM
Gene Ontology
Molecular Function
GO:0000721 (R,R)-butanediol dehydrogenase activity
GO:0003824 catalytic activity
GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0046526 D-xylulose reductase activity
GO:0046872 metal ion binding
GO:0047833 D-sorbitol dehydrogenase (acceptor) activity
GO:0050255 ribitol 2-dehydrogenase (NAD+) activity
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006060 sorbitol metabolic process
GO:0006062 sorbitol catabolic process
GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate
GO:0030317 flagellated sperm motility
GO:0046370 fructose biosynthetic process
GO:0051160 xylitol catabolic process
GO:0051164 xylitol metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0031514 motile cilium
GO:0031966 mitochondrial membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pl6, PDBe:1pl6, PDBj:1pl6
PDBsum1pl6
PubMed12962626
UniProtQ00796|DHSO_HUMAN Sorbitol dehydrogenase (Gene Name=SORD)

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