Structure of PDB 1pkg Chain A

Receptor sequence
>1pkgA (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA
AMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPT
LVITEYCCYGDLLNFLRRKRDSFICSKALDLEDLLSFSYQVAKGMAFLAS
KNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKW
MAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE
GFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQ
3D structure
PDB1pkg Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D792 R796 N797 D810
Catalytic site (residue number reindexed from 1) D157 R161 N162 D175
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G596 G598 F600 G601 V603 A621 K623 C673 D677 R796 N797 L799 D810 G30 G32 F34 G35 V37 A55 K57 C107 D111 R161 N162 L164 D175
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1pkg, PDBe:1pkg, PDBj:1pkg
PDBsum1pkg
PubMed12824176
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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