Structure of PDB 1pj6 Chain A

Receptor sequence
>1pj6A (length=828) Species: 1665 (Arthrobacter globiformis) [Search protein sequence]
STPRIVIIGAGIVGTNLADELVTRGWNNITVLDQGPLNMPGGSTSHAPGL
VFQTNPSKTMASFAKYTVEKLLSLTEDGVSCFNQVGGLEVATTETRLADL
KRKLGYAAAWGIEGRLLSPAECQELYPLLDGENILGGLHVPSDGLASAAR
AVQLLIKRTESAGVTYRGSTTVTGIEQSGGRVTGVQTADGVIPADIVVSC
AGFWGAKIGAMIGMAVPLLPLAHQYVKTTPVPAQQGRNDQPNGARLPILR
HQDQDLYYREHGDRYGIGSYAHRPMPVDVDTLGAYAPETVSEHHMPSRLD
FTLEDFLPAWEATKQLLPALADSEIEDGFNGIFSFTPDGGPLLGESKELD
GFYVAEAVWVTHSAGVAKAMAELLTTGRSETDLGECDITRFEDVQLTPEY
VSETSQQNFVEIYDVLHPLQPRLSPRNLRVSPFHARHKELGAFFLEAGGW
ERPYWFEANAALLKEMPAEWLPPARDAWSGMFSSPIAAAEAWKTRTAVAM
YDMTPLKRLEVSGPGALKLLQELTTADLAKKPGAVTYTLLLDHAGGVRSD
ITVARLSEDTFQLGANGNIDTAYFERAARHQTQSGSATDWVQVRDTTGGT
CCIGLWGPLARDLVSKVSDDDFTNDGLKYFRAKNVVIGGIPVTAMRLSYV
GELGWELYTSADNGQRLWDALWQAGQPFGVIAAGRAAFSSLRLEKGYRSW
GTDMTTEHDPFEAGLGFAVKMAKESFIGKGALEGRTEEASARRLRCLTID
DGRSIVLGKEPVFYKEQAVGYVTSAAYGYTVAKPIAYSYLPGTVSVGDSV
DIEYFGRRITATVTEDPLYDPKMTRLRG
3D structure
PDB1pj6 Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H225 Y259 D552
Catalytic site (residue number reindexed from 1) H223 Y257 D550
Enzyme Commision number 1.5.3.10: dimethylglycine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G11 G13 I14 V15 D35 Q36 G44 S45 T46 H48 P50 L52 V174 A203 G204 W206 H225 Y259 G333 I334 V360 W361 V362 T363 G9 G11 I12 V13 D33 Q34 G42 S43 T44 H46 P48 L50 V172 A201 G202 W204 H223 Y257 G331 I332 V358 W359 V360 T361
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047866 dimethylglycine oxidase activity

View graph for
Molecular Function
External links
PDB RCSB:1pj6, PDBe:1pj6, PDBj:1pj6
PDBsum1pj6
PubMed12912903
UniProtQ9AGP8|DMGO_ARTGO Dimethylglycine oxidase (Gene Name=dmg)

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