Structure of PDB 1pj5 Chain A

Receptor sequence
>1pj5A (length=827) Species: 1665 (Arthrobacter globiformis) [Search protein sequence]
TPRIVIIGAGIVGTNLADELVTRGWNNITVLDQGPLNMPGGSTSHAPGLV
FQTNPSKTMASFAKYTVEKLLSLTEDGVSCFNQVGGLEVATTETRLADLK
RKLGYAAAWGIEGRLLSPAECQELYPLLDGENILGGLHVPSDGLASAARA
VQLLIKRTESAGVTYRGSTTVTGIEQSGGRVTGVQTADGVIPADIVVSCA
GFWGAKIGAMIGMAVPLLPLAHQYVKTTPVPAQQGRNDQPNGARLPILRH
QDQDLYYREHGDRYGIGSYAHRPMPVDVDTLGAYAPETVSEHHMPSRLDF
TLEDFLPAWEATKQLLPALADSEIEDGFNGIFSFTPDGGPLLGESKELDG
FYVAEAVWVTHSAGVAKAMAELLTTGRSETDLGECDITRFEDVQLTPEYV
SETSQQNFVEIYDVLHPLQPRLSPRNLRVSPFHARHKELGAFFLEAGGWE
RPYWFEANAALLKEMPAEWLPPARDAWSGMFSSPIAAAEAWKTRTAVAMY
DMTPLKRLEVSGPGALKLLQELTTADLAKKPGAVTYTLLLDHAGGVRSDI
TVARLSEDTFQLGANGNIDTAYFERAARHQTQSGSATDWVQVRDTTGGTC
CIGLWGPLARDLVSKVSDDDFTNDGLKYFRAKNVVIGGIPVTAMRLSYVG
ELGWELYTSADNGQRLWDALWQAGQPFGVIAAGRAAFSSLRLEKGYRSWG
TDMTTEHDPFEAGLGFAVKMAKESFIGKGALEGRTEEASARRLRCLTIDD
GRSIVLGKEPVFYKEQAVGYVTSAAYGYTVAKPIAYSYLPGTVSVGDSVD
IEYFGRRITATVTEDPLYDPKMTRLRG
3D structure
PDB1pj5 Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.
ChainA
Resolution1.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H225 Y259 D552
Catalytic site (residue number reindexed from 1) H222 Y256 D549
Enzyme Commision number 1.5.3.10: dimethylglycine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G11 G13 I14 V15 D35 Q36 G44 S45 T46 H48 P50 L52 T173 V174 A203 G204 W206 H225 Y259 G333 I334 F335 V360 W361 V362 T363 G8 G10 I11 V12 D32 Q33 G41 S42 T43 H45 P47 L49 T170 V171 A200 G201 W203 H222 Y256 G330 I331 F332 V357 W358 V359 T360
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047866 dimethylglycine oxidase activity

View graph for
Molecular Function
External links
PDB RCSB:1pj5, PDBe:1pj5, PDBj:1pj5
PDBsum1pj5
PubMed12912903
UniProtQ9AGP8|DMGO_ARTGO Dimethylglycine oxidase (Gene Name=dmg)

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