Structure of PDB 1pig Chain A

Receptor sequence
>1pigA (length=496) Species: 9823 (Sus scrofa) [Search protein sequence]
QYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENVV
VTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVIN
HMCGSGAAAGTGTTCGSYCNPGSREFPAVPYSAWDFNDGKCKTASGGIES
YNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASK
HMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAISSSEYFGN
GRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHD
NQRGHGAGGSSILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVN
GEDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWREIRNMVWFRNV
VDGQPFANWWDNGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYC
NVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAQDPFIAIHAESKL
3D structure
PDB1pig Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.1: alpha-amylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A W58 W59 Q63 H305 W58 W59 Q63 H305 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS02 AGL A W59 V163 W59 V163 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS03 GLC A Y151 K200 E240 Y151 K200 E240 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS04 AGL A A198 H201 E233 D300 A198 H201 E233 D300 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS05 GLC A K322 W388 E390 K322 W388 E390 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS06 GLC A R387 W388 R389 E390 R387 W388 R389 E390 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS07 GLC A E272 W284 E272 W284 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS08 BGC A K261 G283 W284 K261 G283 W284 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS09 HMC A W58 H101 D197 E233 H299 D300 W58 H101 D197 E233 H299 D300 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS10 BGC A T439 Y468 S470 T474 A475 T439 Y468 S470 T474 A475 PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BS11 CA A N100 R158 D167 H201 N100 R158 D167 H201
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004556 alpha-amylase activity
GO:0005509 calcium ion binding
GO:0016160 amylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0031404 chloride ion binding
GO:0043169 cation binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0016052 carbohydrate catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1pig, PDBe:1pig, PDBj:1pig
PDBsum1pig
PubMed8757803
UniProtP00690|AMYP_PIG Pancreatic alpha-amylase (Gene Name=AMY2)

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