Structure of PDB 1ph1 Chain A

Receptor sequence

>1ph1A (length=456) Species: 200597 (Sterkiella nova)

KYEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLY
LKQDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQFNAN
VFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNEISIL
QNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHELDEY
TNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQKKVLI
LSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVLTEVD
KKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKEWVKG
YDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYTQDGL
GANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGFYLIK
DTKLIY

3D structure

• PDB: 1ph1 Nucleotide Shuffling and Ssdna Recognition in Oxytricha Nova Telomere End-Binding Protein Complexes
• Chain: A
• Resolution: 2.51 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K105 N139 F141 Y142	K66 N100 F102 Y103
BS02	dna	A	F63 Y65 K66 T67 N68 R71 Y72 I73 S75 K77 V101 Y103 F107 I112 Y130 Q135 D223 D225 Y239 L260 K261 R274 S275 H292 Y293	F29 Y31 K32 T33 N34 R37 Y38 I39 S41 K43 V62 Y64 F68 I73 Y91 Q96 D184 D186 Y200 L221 K222 R235 S236 H253 Y254

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1ph1, PDBe:1ph1, PDBj:1ph1
• PDBsum: 1ph1
• PubMed: 12912928
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)