Structure of PDB 1pgu Chain A

Receptor sequence
>1pguA (length=606) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDS
KVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKES
NSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN
SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRT
HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP
VQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ
VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLI
SGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGIT
KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSA
VSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSET
YIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWKPAEEIEEDLVA
TGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACI
KRWNVV
3D structure
PDB1pgu The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H368 D370 H367 D369
BS02 ZN A H328 E330 H327 E329
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0030042 actin filament depolymerization
GO:0032466 negative regulation of cytokinesis
GO:0051016 barbed-end actin filament capping
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0030479 actin cortical patch
GO:0030864 cortical actin cytoskeleton
GO:0043332 mating projection tip

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pgu, PDBe:1pgu, PDBj:1pgu
PDBsum1pgu
PubMed12807914
UniProtP46680|AIP1_YEAST Actin-interacting protein 1 (Gene Name=AIP1)

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