Structure of PDB 1pgq Chain A

Receptor sequence

>1pgqA (length=473) Species: 9940 (Ovis aries)

AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTK
VLGAHSLEEMVSKLKKPRRIILLVKAGQAVDNFIEKLVPLLDIGDIIIDG
GNSEYRDTMRRCRDLKDKGILFVGSGVSGGEDGARYGPSLMPGGNKEAWP
HIKAIFQGIAAKVGTGEPCCDWVGDDGAGHFVKMVHNGIEYGDMQLICEA
YHLMKDVLGLGHKEMAKAFEEWNKTELDSFLIEITASILKFQDADGKHLL
PKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQAS
KKLKGPQNIPFEGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGW
TLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVEN
CQDSWRRAISTGVQAGIPMPCFTTALSFYDGYRHAMLPANLIQAQRDYFG
AHTYELLAKPGQFIHTNWTGHGG

3D structure

• PDB: 1pgq Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
• Chain: A
• Resolution: 3.17 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S128 K183 H186 N187 E190
• Catalytic site (residue number reindexed from 1): S128 K183 H186 N187 E190
• Enzyme Commision number: 1.1.1.44: phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2AM	A	N32 R33 T34 V74 K75 A79 F83	N32 R33 T34 V74 K75 A79 F83

Gene Ontology

Molecular Function

• GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
• GO:0016491 oxidoreductase activity
• GO:0050661 NADP binding

Biological Process

• GO:0006098 pentose-phosphate shunt
• GO:0009051 pentose-phosphate shunt, oxidative branch
• GO:0019521 D-gluconate metabolic process
• GO:0046177 D-gluconate catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1pgq, PDBe:1pgq, PDBj:1pgq
• PDBsum: 1pgq
• PubMed: 7922042
• UniProt: P00349|6PGD_SHEEP 6-phosphogluconate dehydrogenase, decarboxylating (Gene Name=PGD)