Structure of PDB 1pcg Chain A

Receptor sequence
>1pcgA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKSKNVVPLYDLLLEMLDAH
3D structure
PDB1pcg Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E542 I54 K58 L68 V72 E227
BS02 EST A E353 L387 F404 H524 L525 E49 L83 F100 H209 L210 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1pcg, PDBe:1pcg, PDBj:1pcg
PDBsum1pcg
PubMed13679575
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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