Structure of PDB 1pca Chain A

Receptor sequence
>1pcaA (length=402) Species: 9823 (Sus scrofa) [Search protein sequence]
KEDFVGHQVLRISVDDEAQVQKVKELEDLEHLQLDFWRGPARPGFPIDVR
VPFPSIQAVKVFLEAHGIRYTIMIEDVQLLLDEEQEQMFASQGRARTTST
FNYATYHTLEEIYDFMDILVAEHPALVSKLQIGRSYEGRPIYVLKFSTGG
SNRPAIWIDSGIHSREWITQASGVWFAKKITENYGQNSSFTAILDSMDIF
LEIVTNPNGFAFTHSDNRLWRKTRSKASGSLCVGSDSNRNWDAGFGGAGA
SSSPCAETYHGKYPNSEVEVKSITDFVKNNGNIKAFISIHSYSQLLLYPY
GYKTQSPADKSELNQIAKSAVAALKSLYGTSYKYGSIITVIYQASGGVID
WTYNQGIKYSFSFELRDTGRRGFLLPASQIIPTAQETWLALLTIMEHTLN
NS
3D structure
PDB1pca Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H163 E166 R221 H290 E364
Enzyme Commision number 3.4.17.1: carboxypeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H69 E72 H196 H163 E166 H290
BS02 VAL A N144 R145 Y248 E270 N238 R239 Y342 E364
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1pca, PDBe:1pca, PDBj:1pca
PDBsum1pca
PubMed1548696
UniProtP09954|CBPA1_PIG Carboxypeptidase A1 (Gene Name=CPA1)

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