Structure of PDB 1pbq Chain A

Receptor sequence
>1pbqA (length=274) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGVPQCCYGF
CIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSG
QADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKGTRITGINDPRLRN
PSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN
KLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSL
SILKSHENGFMEDLDKTWVRYQEC
3D structure
PDB1pbq Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DK1 A Q13 F16 F92 P124 L125 T126 R131 W223 D224 F250 Q9 F12 F76 P108 L109 T110 R115 W207 D208 F234 MOAD: Ki=0.54uM
PDBbind-CN: -logKd/Ki=6.27,Ki=0.54uM
BindingDB: Ki=40nM,EC50=330nM,IC50=860nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1pbq, PDBe:1pbq, PDBj:1pbq
PDBsum1pbq
PubMed12805203
UniProtP35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)

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