Structure of PDB 1pbk Chain A

Receptor sequence
>1pbkA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
PKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKKKKN
AKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKI
PPNAKLTFEVELVDID
3D structure
PDB1pbk Atomic Structure of the Rapamycin Human Immunophilin Fkbp-12 Complex
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y135 F145 D146 I172 Y198 F216
Catalytic site (residue number reindexed from 1) Y27 F37 D38 I64 Y90 F108
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAP A Y135 D146 L162 G169 K170 V171 W175 Y198 I208 Y27 D38 L54 G61 K62 V63 W67 Y90 I100 MOAD: Ki=0.9nM
PDBbind-CN: -logKd/Ki=9.05,Ki=0.9nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:1pbk, PDBe:1pbk, PDBj:1pbk
PDBsum1pbk
PubMed
UniProtQ00688|FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3 (Gene Name=FKBP3)

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