Structure of PDB 1pb8 Chain A

Receptor sequence
>1pb8A (length=282) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNRHTVP
QCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMM
GELLSGQADMIVAPLTINTERAQYIEFSKPFKYQGLTILVKKGTRITGIN
DPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAI
QAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPW
KQNVSLSILKSHENGFMEDLDKTWVRYQECDS
3D structure
PDB1pb8 Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DSN A F92 T126 R131 S179 S180 W223 D224 F82 T116 R121 S169 S170 W213 D214 MOAD: Ki=7.02uM
PDBbind-CN: -logKd/Ki=5.15,Ki=7.02uM
BindingDB: IC50=670.0nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1pb8, PDBe:1pb8, PDBj:1pb8
PDBsum1pb8
PubMed12805203
UniProtP35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)

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