Structure of PDB 1pa9 Chain A

Receptor sequence
>1pa9A (length=279) Species: 630 (Yersinia enterocolitica) [Search protein sequence]
VSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCR
RQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVL
ASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLT
IREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYES
KGSDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQ
RNGIMVQKDEQLDVLIKLAEGQGRPLLNS
3D structure
PDB1pa9 Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E128 W192 D194 H240 C241 R247 T248
Catalytic site (residue number reindexed from 1) E105 W169 D171 H213 C214 R220 T221
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CSN A F67 I70 D194 Q195 C241 R242 A243 V245 G246 R247 Q284 F44 I47 D171 Q172 C214 R215 A216 V218 G219 R220 Q257 MOAD: Ki=25uM
PDBbind-CN: -logKd/Ki=4.60,Ki=25uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1pa9, PDBe:1pa9, PDBj:1pa9
PDBsum1pa9
PubMed12810712
UniProtP15273|YOPH_YEREN Tyrosine-protein phosphatase YopH (Gene Name=yopH)

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