Structure of PDB 1p93 Chain A

Receptor sequence
>1p93A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVK
WAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPD
LIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP
KDGLKSQELFDEIRMTYIKELGKAIVKRSSQNWQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB1p93 The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K579 M593 E755 K53 M67 E226
BS02 peptide A N619 Y640 N93 Y114
BS03 DEX A M560 L563 N564 G567 Q570 M601 M604 R611 Q642 Y735 T739 I747 M34 L37 N38 G41 Q44 M75 M78 R85 Q116 Y206 T210 I218 PDBbind-CN: -logKd/Ki=7.72,Kd=19nM
BindingDB: EC50=2.5nM,Ki=1.2nM,IC50=5nM,Kd=19nM
External links
PDB RCSB:1p93, PDBe:1p93, PDBj:1p93
PDBsum1p93
PubMed12686538
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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