Structure of PDB 1p91 Chain A

Receptor sequence
>1p91A (length=268) Species: 562 (Escherichia coli) [Search protein sequence]
SFSCPLCHQPLSREKNSYICPQRHQFDMAKEGYVNLLPVQHKRSRDPGDS
AEMMQARRAFLDAGHYQPLRDAIVAQLRERLDDKATAVLDIGCGEGYYTH
AFADALPEITTFGLDVSKVAIKAAAKRYPQVTFCVASSHRLPFSDTSMDA
IIRIYAPCKAEELARVVKPGGWVITATPGPRHLMELKGLIYNEVHLHAPH
AEQLEGFTLQQSAELCYPMRLRGDEAVALLQMTPFAWRAKPEVWQTLAAK
EVFDCQTDFNIHLWQRSY
3D structure
PDB1p91 Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.187: 23S rRNA (guanine(745)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C5 C8 H25 C4 C7 H24
BS02 SAM A L62 Y67 C94 G95 E96 G97 Y99 I155 Y156 T178 P179 L61 Y66 C93 G94 E95 G96 Y98 I154 Y155 T177 P178
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008989 rRNA (guanine-N1-)-methyltransferase activity
GO:0046872 metal ion binding
GO:0052911 23S rRNA (guanine(745)-N(1))-methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0032259 methylation
GO:0070475 rRNA base methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1p91, PDBe:1p91, PDBj:1p91
PDBsum1p91
PubMed14999102
UniProtP36999|RLMA_ECOLI 23S rRNA (guanine(745)-N(1))-methyltransferase (Gene Name=rlmA)

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