Structure of PDB 1p8d Chain A

Receptor sequence
>1p8dA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
VQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLQSRDARQQRFAHF
TELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYN
HETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYA
LLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
3D structure
PDB1p8d X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V283 K287 R297 I301 K305 P451 L452 E455 V62 K66 R76 I80 K84 P230 L231 E234
BS02 CO1 A F243 F271 E281 E315 T316 R319 F329 W457 F26 F50 E60 E94 T95 R98 F108 W236 BindingDB: EC50=286nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1p8d, PDBe:1p8d, PDBj:1p8d
PDBsum1p8d
PubMed12736258
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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